Scientific Studies on the Health Benefits of Pomegranate

The mythical pomegranate has been a scientific enigma since biblical times. Recent interest in the therapeutic properties of the pomegranate has resulted in a number of independent clinical studies from scientists around the world that have begun to substantiate the pomegranate's legendary powers. I have included links to some of these independently published studies.

Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12002340&dopt=Abstract

Nam Deuk Kim, Rajendra Mehta, Weiping Yu, Ishak Neeman, Talia Livney, Akiva Amichay, Donald Poirier, Paul Nicholls, Andrew Kirby, Wenguo Jiang, Robert Mansel, Cheppail Ramachandran, Thangaiyan Rabi, Boris Kaplan and Ephraim Lansky Department of Pharmacy, Pusan National University, Pusan, Korea; Department of Surgical Oncology, College of Medicine, University of Illinois, Chicago, IL; School of Biological Sciences, University of Texas at Austin, Austin, TX; Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa, Israel; Rimonest Ltd., Science Park Technion, Nesher, Israel; Laboratory of Molecular Endocrinology, Laval University Medical Research Center, Quebec, Canada; Welsh School of Pharmacy, Redwood Building, Cardiff University; Metastasis Research Unit, Department of Surgery, University of Wales College of Medicine, Cardiff, UK; Research Institute, Miami Children's Hospital, Miami, FL, USA; Department of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv; Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petach Tikva, IsraelBreast Cancer Research and Treatment 71: 203-217, 2002.

Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells.

http://www.liebertonline.com/doi/abs/10.1089/jmf.2004.7.274#search=%22Pomegranate%20extracts%20potently%20suppress%20proliferation%2C%20xenograft%20growth%2C%20and%20invasion%20of%20human%20prostate%20cancer%20cells.%22

Albrecht M, Jiang W, Kumi-Diaka J, Lansky EP, Gommersall LM, Patel A, Mansel RE, Neeman I, Geldof AA, Campbell MJ.Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany.J Med Food. 2004 Fall;7(3):274-83.

Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across matrigel

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15744587&dopt=Abstract

Ephraim Philip Lansky, Gregory Harrison, Paul Froom and Wen G. JiangRimonest Ltd., P.O.B. 9945, Haifa, Israel; Metastasis and Angiogenesis Research Group, University of Wales, College of Medicine, Cardiff, UK; Department of Epidemiology and Preventive Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelInvestigational New Drugs 23: 121-122, 2005.

Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions

http://www.springerlink.com/content/kkt75w5k2081832p

Ephraim P. Lansky, Wenguo Jiang, Huanbiao Mo, Lou Bravo, Paul Froom, Weiping Yu, Neil M. Harris, Ishak Neeman and Moray J. Campbell Rimonest Ltd, Horev Center, Box 9945, Haifa, Israel; University Department of Surgery, University of Wales College of Medicine, Cardiff, UK; Department of Nutrition and Food Science, Texas Women's University, Denton, TX, USA; Department of Epidemiology and Preventive Medicine, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; School of Biological Sciences, University of Texas at Austin, Austin, TX, USA; Department of Urology, Royal Bournemouth Hospital, Bournemouth, UK; Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa, Israel; Division of Medical Sciences, University of Birmingham Medical School, Birmingham, UKInvestigational New Drugs 23: 11-20, 2005

Chemopreventive Effects of Pomegranate Seed Oil on Skin Tumor Development in CD Mice

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16221534&dopt=Abstract

Justin J. Hora, Emily R. Maydew, Ephraim P. Lansky, and Chandradhar DwivediDepartment of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, USA; and Rimonest Ltd., Horev Center, Haifa, IsraelJournal of Medicinal Food, J Med Food 6 (3) 2003, 157-161.

Pomegranate as a cosmeceutical source: Pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells.

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16221534&dopt=Abstract

Aslam MN, Lansky EP, Varani J.Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road/Box 0602, Ann Arbor, MI 48109, USA.J Ethnopharmacol. 2006 Feb 20;103(3):311-8. Epub 2005 Oct 10.

Dietary effect of a pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic OLETF Rats

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=534798

Keisuke Arao, Yu-Ming Wang, Nao Inoue, Junichi Hirata, Jae-Young Cha, Koji Nagao and Teruyoshi YanagitaDepartment of Applied Biological Sciences, Saga University, Saga 840-8502, JapanLipids in Health and Disease 2004, 3:24.

Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=14732284&dopt=Abstract

Danny A. van Elswijk, Uwe P. Schobel, Ephraim Lansky, Hubertus Irth, Jan van der GreefKiadis, Niels Bohrweg 11-13, 2333 AC, Leiden, The Netherlan; Rimonest Ltd., Science Park Technion, Nesher, Israel; Department of Analytical Chemistry and Applied Spectroscopy, Vrije Universiteit, Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands; Leiden-Amsterdam Center for Drug Research, Division of Analytical Chemistry, University of Leiden, PO Box 9502, 2300 RA, Leiden, The Netherlands.Phytochemistry 65 (2004) 233-241

Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=14739618&dopt=Abstract

Masakazu Toi, Hiroko Bando, Cheppail Ramachandran, Steven J. Melnick, Atsushi Imai, Rose S. Fife, Raymond Eric Carr, Tsutomu Oikawa & Ephraim Philip LanskyDepartment of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Research Institute, Miami Children's Hospital, Miami, FL, USA; Department of Obstetrics and Gynecology, Gifu University, School of Medicine, Tsukasamachi, Gifu, Japan; Department of Medicine, Indiana University of Medicine, Indianapolis, Indiana, USA; Department of Molecular Oncology, The Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan; Rimonest Ltd., Horev Center, Haifa, Israel.Angiogenesis 6: 121-128, 2003.

Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavanoids

http://www.rimonest.com/research11.html

Shay Yehoshua Schubert, Ephraim Philip Lansky, Ishak NeemanLaboratories of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa32000, Israel; Rimoni Corporation, Science Park, Nesher, IsraelJournal of Ethnopharmacology 66 (1999) 11-17..